钙调蛋白抑制与大鼠肥大细胞介质释放之间的关系。
Relation between inhibition of calmodulin and mediator release from rat mast cells.
作者信息
Ohishi K, Suzuki T, Uchida M K
出版信息
Gen Pharmacol. 1985;16(4):335-9. doi: 10.1016/0306-3623(85)90192-2.
PMID:2412934
Abstract
Cationic drugs that interact with calmodulin such as chlorpromazine, trifluoperazine, W-7 and lidocaine caused dose-dependent release of mediator from rat mast cells. A significant correlation was observed between the effects of test drugs with different structure in causing mediator release and calmodulin inhibition.
摘要
与钙调蛋白相互作用的阳离子药物，如氯丙嗪、三氟拉嗪、W-7和利多卡因，可引起大鼠肥大细胞介质的剂量依赖性释放。在不同结构的受试药物引起介质释放的作用与钙调蛋白抑制之间观察到显著相关性。
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