手性烯烃-亚砜作为手性配体用于铑催化的芳基硼酸对不饱和酯的不对称共轭加成反应。
Chiral olefin-sulfoxide as ligands for rhodium-catalyzed asymmetric conjugate addition of arylboronic acids to unsaturated esters.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, P. R. China.
出版信息
Org Biomol Chem. 2013 Dec 7;11(45):7893-8. doi: 10.1039/c3ob41342j. Epub 2013 Oct 16.
PMID:24129394
Abstract
An efficient rhodium/olefin-sulfoxide catalyzed asymmetric conjugate addition of organoboronic acids to various unsaturated esters has been developed, where 2-methoxy-1-naphthyl sulfinyl functionalized olefin ligands have been shown to be highly effective, and are especially applicable to unsaturated methyl esters with up to 99% yield and 91% ee.
摘要
发展了一种高效的铑/烯烃-亚砜催化的有机硼酸对各种不饱和酯的不对称共轭加成反应，其中 2-甲氧基-1-萘基亚砜功能化的烯烃配体非常有效，特别适用于不饱和甲酯，产率高达 99%，对映选择性为 91%。
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