通过心率变异性评估的心脏交感神经活动表明糖尿病患者在冷暴露时存在心肌缺血。
Cardiac sympathetic activity assessed by heart rate variability indicates myocardial ischemia on cold exposure in diabetes.
作者信息
Sasaki Keita, Matsushita Shonosuke, Sato Fujio, Tokunaga Chiho, Hyodo Kazuyuki, Sakakibara Yuzuru
机构信息
School of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
出版信息
Ann Vasc Dis. 2013;6(3):583-9. doi: 10.3400/avd.cr.13-00064. Epub 2013 Sep 5.
Measurement of heart rate variability (HRV) is a non-invasive technique that can be used to investigate functioning of the autonomic nervous system, especially the balance between sympathetic and vagal activities. It is reported that dilatation of coronary microcirculation by augmentation of sympathetic nerve activity (SNA) caused by cold exposure was impaired in diabetes. The question of whether or not SNA in HRV could respond to coronary ischemia was evaluated by cold exposure in diabetic rats. It was found that diabetes with weight loss significantly increased SNA both in baseline and cold exposure, compared with control. A correspondence was also found with coronary ischemia. It can be concluded that measurement of HRV may provide useful information regarding the coronary risk of cold exposure in diabetes. (English translation of J Jpn Coll Angiol 2012; 52: 295-301).
心率变异性（HRV）测量是一种非侵入性技术，可用于研究自主神经系统的功能，尤其是交感神经和迷走神经活动之间的平衡。据报道，糖尿病患者因冷暴露引起的交感神经活动（SNA）增强导致的冠状动脉微循环扩张受损。通过对糖尿病大鼠进行冷暴露，评估了HRV中的SNA是否能对冠状动脉缺血作出反应。结果发现，与对照组相比，体重减轻的糖尿病患者在基线和冷暴露时SNA均显著增加。还发现其与冠状动脉缺血有关。可以得出结论，HRV测量可能为糖尿病患者冷暴露的冠状动脉风险提供有用信息。（《日本血管外科学会杂志》2012年；52：295 - 301的英文翻译）
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