Apostolopoulos Diane, Hoi Alberta Yik-Bun
B BiomedSci, MBBS, Rheumatology Registrar, Department of Rheumatology, Monash Health, Melbourne, Victoria.
Aust Fam Physician. 2013 Oct;42(10):696-700.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by multi-system manifestations. It is regarded as the prototypal connective tissue disease, where the key pathogenesis relates to a dysfunctional immune system that results in over-production of various autoantibodies. Most of its pathology is mediated by either direct or indirect effects of these autoantibodies, as well as other components of the innate and adaptive immune systems.
系统性红斑狼疮（SLE）是一种以多系统表现为特征的慢性自身免疫性疾病。它被视为典型的结缔组织病，其关键发病机制与免疫系统功能失调有关，导致各种自身抗体过度产生。其大部分病理是由这些自身抗体以及固有免疫系统和适应性免疫系统的其他成分的直接或间接作用介导的。
