López-Mejías R, Genre F, García-Bermúdez M, Castañeda S, González-Juanatey C, Llorca J, Corrales A, Miranda-Filloy J A, Rueda-Gotor J, Gómez-Vaquero C, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, López-Longo F J, Carreira P, Blanco R, González-Álvaro I, Martín J, González-Gay M A
Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.
Tissue Antigens. 2013 Nov;82(5):344-7. doi: 10.1111/tan.12217.
Rheumatoid arthritis (RA) is an inflammatory disease associated with high risk of cardiovascular (CV) events. Recently, the rs964184 polymorphism has been associated with coronary artery disease in nonrheumatic Caucasian individuals. 2160 Spanish RA patients were genotyped for the rs964184 polymorphism. Sex, age at diagnosis and traditional CV risk factors (diabetes mellitus, dyslipidemia and smoking habit) were associated with increased risk of CV events. Interestingly, RA patients carrying the rs964184 GG genotype had significantly higher risk of CV events than those with CC genotype [hazard ratio (HR) = 2.91, 95% confidence interval (CI): 1.36-6.26, P = 0.006] after adjusting the results for sex, age at diagnosis and traditional CV risk factors. Our results indicate that rs964184 polymorphism is associated with CV disease in RA.
类风湿关节炎（RA）是一种与心血管（CV）事件高风险相关的炎症性疾病。最近，rs964184多态性已与非风湿性白种人个体的冠状动脉疾病相关联。对2160名西班牙RA患者进行了rs964184多态性的基因分型。性别、诊断时年龄和传统CV危险因素（糖尿病、血脂异常和吸烟习惯）与CV事件风险增加相关。有趣的是，在对性别、诊断时年龄和传统CV危险因素的结果进行调整后，携带rs964184 GG基因型的RA患者发生CV事件的风险显著高于携带CC基因型的患者[风险比（HR）=2.91，95%置信区间（CI）：1.36 - 6.26，P = 0.006]。我们的结果表明，rs964184多态性与RA中的CV疾病相关。
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