Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, s/n 39008 Santander, Spain.
Atherosclerosis. 2012 Oct;224(2):426-9. doi: 10.1016/j.atherosclerosis.2012.06.008. Epub 2012 Jun 13.
Rheumatoid arthritis (RA) is an inflammatory disease associated with increased cardiovascular (CV) mortality. A recent study has disclosed association between NFKB1-94ATTG ins/del polymorphism and higher risk of coronary heart disease in healthy Caucasians. Because of that, we assessed the influence of this polymorphism in the risk of CV disease in RA patients.
1437 Spanish patients with RA were genotyped for the NFKB1-94ATTG ins/del polymorphism. Two hundred and seventy-one of them (18.8%) had experienced CV events.
After adjusting for sex, age at RA diagnosis and traditional CV risk factors RA patients carrying the NFKB1 del/del genotype had higher risk of CV events than those with ins/ins genotype (Hazard ratio [HR] = 1.76, 95% CI: 1.05-2.97, p = 0.03), while heterozygous patients had an intermediate (but non-significant) risk (HR = 1.31, 95% CI: 0.90-1.92, p = 0.16).
Our results suggest that NFKB1-94ATTG ins/del polymorphism is associated with CV disease in patients with RA.
类风湿关节炎（RA）是一种炎症性疾病，与心血管（CV）死亡率增加有关。最近的一项研究揭示了 NFKB1-94ATTG ins/del 多态性与健康白种人患冠心病风险增加之间的关联。因此，我们评估了这种多态性在 RA 患者发生 CV 疾病风险中的影响。
对 1437 名西班牙 RA 患者进行了 NFKB1-94ATTG ins/del 多态性基因分型。其中 271 名（18.8%）发生过 CV 事件。
在调整了性别、RA 诊断时的年龄和传统 CV 危险因素后，携带 NFKB1 del/del 基因型的 RA 患者发生 CV 事件的风险高于携带 ins/ins 基因型的患者（风险比 [HR] = 1.76，95%可信区间：1.05-2.97，p = 0.03），而杂合子患者的风险则处于中间水平（但无统计学意义）（HR = 1.31，95%可信区间：0.90-1.92，p = 0.16）。
我们的结果表明，NFKB1-94ATTG ins/del 多态性与 RA 患者的 CV 疾病有关。
