Tomoike H, Nose Y, Nakagaki O, Fukuyama T, Kuroiwa A, Nakamura M
Arzneimittelforschung. 1975 May;25(5):765-9.
Effects of beta-blockers o-[2-hydroxy-3-(tert.-butylamino)-propoxy]-benzonitrile (Kö 136 1366) and propranolol, on regional Rb86 clearance in the dog myocardium under selective coronary hypotension were investigated. Selective coronary hypotension of the left circumflex artery below 50 mmHg significantly decreased the Rb86 clearance and its I/O ratio of the involved myocardium. Kö 1366 and propranolol had a general trend to decrease the regional Rb86 clearance in the non-ischaemic region and to increase it in the ischaemic region when compared with that of the control group. Therefore, the gradient of regional Rb86 clearance between the non-ischaemic and ischaemic region may decrease. However, these changes were not statistically significant. Although both Kö 1366 and propranolol groups demonstrated similar haemodynamic changes, a reduction in heart rate was larger with propranolol infusion than with Kö 1366. On the contrary, a decreasing rate in systemic arterial blood pressure was marked with Kö 1366. Epicardial ECG ST elevation was reduced after propranolol infusion, not after saline or KO 1366 infusion.
研究了β受体阻滞剂邻-[2-羟基-3-(叔丁基氨基)-丙氧基]-苯甲腈（Kö 136 1366）和普萘洛尔在选择性冠状动脉低血压情况下对犬心肌局部铷86清除率的影响。左旋支动脉选择性冠状动脉低血压低于50 mmHg时，可显著降低受累心肌的铷86清除率及其摄取/清除率比值。与对照组相比，Kö 1366和普萘洛尔总体上有降低非缺血区局部铷86清除率和增加缺血区局部铷86清除率的趋势。因此，非缺血区和缺血区之间局部铷86清除率的梯度可能减小。然而，这些变化无统计学意义。虽然Kö 1366组和普萘洛尔组均表现出相似的血流动力学变化，但输注普萘洛尔时心率降低幅度大于输注Kö 1366时。相反，输注Kö 1366时体动脉血压下降幅度明显。输注普萘洛尔后心外膜心电图ST段抬高降低，输注生理盐水或Kö 1366后则未降低。
