Shao Guang-Jun, Cai Lin, Li Xue-Song, Song Gang, Li Xue-Ying, He Zhi-Song, Zhou Li-Qun
Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Beijing 100034, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2013 Oct 18;45(5):774-8.
To summarize more than thirty years of experience with urachal carcinoma and to discuss the clinical features of urachal carcinoma.
The clinical data of 22 patients with urachal carcinoma, 18 males and 4 females, their median age at diagnosis was 52 years (range: 31-77 years), were analyzed retrospectively.
Twenty-one cases were urachal adenocarcinoma, and 1 was small cell carcinoma. The first common symptom was gross hematuria in the urachal carcinoma patients (20/22, 90.9%), and CT showed calcification in 18.75% of them (3/16). The cystoscopic finding was a mass seen at the dome of the bladder or anterior wall in all. Twenty cases were followed up (90.9%), with the median follow-up 28 months (range: 3-184 months). The overall 5-year cancer-specific survival rate was 49.5%. It was significantly different in survival between T2 and T3 or more in the urachal carcinoma patients by survival analysis (P=0.026).
The results indicate that the most important predictor of prognosis is tumor stage, and it is critical for diagnosis of urachal carcinoma by CT scan and cystoscopy. Extended partial cystectomy is the main surgery of patients with urachal carcinoma. Active multimodal treatments may improve the survival of patients with recurrent and metastatic disease.
总结三十多年来脐尿管癌的治疗经验，并探讨脐尿管癌的临床特征。
回顾性分析22例脐尿管癌患者的临床资料，其中男性18例，女性4例，诊断时的中位年龄为52岁（范围：31 - 77岁）。
21例为脐尿管腺癌，1例为小细胞癌。脐尿管癌患者最常见的首发症状是肉眼血尿（20/22，90.9%），CT显示18.75%（3/16）的患者有钙化。膀胱镜检查均发现膀胱顶部或前壁有肿物。20例患者进行了随访（90.9%），中位随访时间为28个月（范围：3 - 184个月）。5年癌症特异性总生存率为49.5%。生存分析显示，脐尿管癌患者中T2期与T3期及以上患者的生存率有显著差异（P = 0.026）。
结果表明，预后的最重要预测因素是肿瘤分期，CT扫描和膀胱镜检查对脐尿管癌的诊断至关重要。扩大性部分膀胱切除术是脐尿管癌患者的主要手术方式。积极的多模式治疗可能提高复发和转移性疾病患者的生存率。
Zotero 插件