Niu H T, Dong P, Wang J N, Huang J, Zeng Y X
Department of Medical Oncology, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing 100021, China.
Department of Oncology, Cancer Hospital of Zibo Wanjie Shangdong, Zibo 255000, China.
Zhonghua Yi Xue Za Zhi. 2016 Jun 28;96(24):1923-5. doi: 10.3760/cma.j.issn.0376-2491.2016.24.011.
Urachal carcinoma is a kind of urogenital tract malignancy with a very low incidence. The objective of this study was to observe the clinical presentation, pathological condition, treatment method and outcome of patients with urachal carcinoma.
A retrospective analysis of thirty-six cases of urachal carcinoma diagnosed over a period of 10 years from 2003 to 2013 was carried out. All pathologic specimens were reviewed by two separate pathologists. Clinical and histological features, treatment condition, patient follow-up and survival outcome was reviewed and calculated.
The mean age at diagnosis was 53 years. Of the thirty-six patients, twenty-five were male. All patients underwent partial cystectomy with bilateral pelvic lymph node dissection. All cases were adenocarcinoma, including 20 mucinous adenocarcinoma, 7 moderately differentiated adenocarcinoma, 5 poorly differentiated adenocarcinoma, 1 signet ring cell carcinoma, 3 hybrid adenocarcinoma. The Sheldon pathologic stage was stage Ⅱ in 11, Ⅲ in 16 and Ⅳa in 9 cases. All patients received medical oncological therapy. The median follow-up period was 27 months. The median overall survival was 36 months. One-year survival rate was 70% and five-year survival rate was 28%.
Urachal carcinomas are rare and usually at locally advanced stage at diagnosis with a high tendency of metastases. Surgery is a key method of primary treatment and medical oncological therapy may play a role in decreasing the chances of recurrence which still needs to be explained by prospective clinical trials.
脐尿管癌是一种发病率极低的泌尿生殖道恶性肿瘤。本研究的目的是观察脐尿管癌患者的临床表现、病理情况、治疗方法及预后。
对2003年至2013年10年间诊断的36例脐尿管癌患者进行回顾性分析。所有病理标本由两位独立的病理学家进行复查。对临床和组织学特征、治疗情况、患者随访及生存结果进行回顾和计算。
诊断时的平均年龄为53岁。36例患者中，25例为男性。所有患者均接受了膀胱部分切除术及双侧盆腔淋巴结清扫术。所有病例均为腺癌，包括20例黏液腺癌、7例中分化腺癌、5例低分化腺癌、1例印戒细胞癌、3例混合性腺癌。谢尔顿病理分期：Ⅱ期11例，Ⅲ期16例，Ⅳa期9例。所有患者均接受了肿瘤内科治疗。中位随访期为27个月。中位总生存期为36个月。1年生存率为70%，5年生存率为28%。
脐尿管癌罕见，诊断时通常处于局部晚期，转移倾向高。手术是主要治疗的关键方法，肿瘤内科治疗可能在降低复发几率方面发挥作用，这仍需前瞻性临床试验加以阐明。
