Yu Minhao, Zhong Ming, Qiao Zhongdong
Department of Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai 200127, P.R. China.
Oncol Lett. 2013 Sep;6(3):777-780. doi: 10.3892/ol.2013.1456. Epub 2013 Jul 11.
The overexpression of cyclin kinase subunit 2 (CKS2) is tightly correlated with tumor aggressiveness and prognosis in various malignancies, including gastric, breast, liver and prostate cancer. However, whether CKS2 is upregulated in colorectal cancer (CRC) remains unknown. The aim of the present study was to analyze CKS2 expression levels in CRC, and to determine the clinical diagnostic and prognostic values of CKS2 overexpression in CRC patients. CKS2 expression was analyzed at the mRNA and protein levels by quantitative (q)PCR and western blot analysis. CKS2 expression was significantly upregulated in CRC compared with the adjacent non-cancer and normal colorectal tissues. The overexpression of CKS2 was correlated with poor differentiation and the pathological stage. In addition, CKS2 overexpression was correlated with aggressive tumor progression in CRC, which indicated that CKS2 may serve as a good CRC biomarker.
细胞周期蛋白激酶亚基2（CKS2）的过表达与包括胃癌、乳腺癌、肝癌和前列腺癌在内的多种恶性肿瘤的肿瘤侵袭性和预后密切相关。然而，CKS2在结直肠癌（CRC）中是否上调仍不清楚。本研究的目的是分析CRC中CKS2的表达水平，并确定CKS2过表达在CRC患者中的临床诊断和预后价值。通过定量（q）PCR和蛋白质印迹分析在mRNA和蛋白质水平分析CKS2表达。与相邻的非癌和正常结直肠组织相比，CRC中CKS2表达显著上调。CKS2的过表达与低分化和病理分期相关。此外，CKS2过表达与CRC中侵袭性肿瘤进展相关，这表明CKS2可能是一种良好的CRC生物标志物。
