Watson Charles, Lind Christopher R P, Thomas Meghan G
Curtin University, Perth, Australia; Neuroscience Research Australia, Sydney, Australia.
J Anat. 2014 Feb;224(2):95-107. doi: 10.1111/joa.12132. Epub 2013 Oct 21.
The caudal zona incerta is the target of a recent modification of established procedures for deep brain stimulation (DBS) for Parkinson's disease and tremor. The caudal zona incerta contains a number of neuronal populations that are distinct in terms of their cytoarchitecture, connections, and pattern of immunomarkers and is located at a position where a number of major tracts converge before turning toward their final destination in the forebrain. However, it is not clear which of the anatomical features of the region are related to its value as a target for DBS. This paper has tried to identify features that distinguish the caudal zona incerta of rodents (mouse and rat) and primates (marmoset, rhesus monkey, and human) from the remainder of the zona incerta. We studied cytoarchitecture, anatomical relationships, the pattern of immunomarkers, and gene expression in both of these areas. We found that the caudal zona incerta has a number of histological and gene expression characteristics that distinguish it from the other subdivisions of the zona incerta. Of particular note are the sparse population of GABA neurons and the small but distinctive population of calbindin neurons. We hope that a clearer appreciation of the anatomy of the region will in the end assist the interpretation of cases in which DBS is used in human patients.
尾侧未定带是帕金森病和震颤深部脑刺激（DBS）既定程序近期改良的靶点。尾侧未定带包含一些神经元群体，它们在细胞结构、连接以及免疫标记模式方面各不相同，且位于多个主要神经束在转向其在前脑的最终目的地之前汇聚的位置。然而，该区域的哪些解剖学特征与其作为DBS靶点的价值相关尚不清楚。本文试图确定将啮齿动物（小鼠和大鼠）和灵长类动物（狨猴、恒河猴和人类）的尾侧未定带与未定带的其余部分区分开来的特征。我们研究了这两个区域的细胞结构、解剖关系、免疫标记模式和基因表达。我们发现，尾侧未定带具有一些组织学和基因表达特征，使其与未定带的其他亚区区分开来。特别值得注意的是GABA能神经元的稀疏群体和小而独特的钙结合蛋白神经元群体。我们希望对该区域解剖结构的更清晰认识最终将有助于解释在人类患者中使用DBS的病例。
