Joyce P R
Aust N Z J Psychiatry. 1985 Jun;19(2):120-7. doi: 10.3109/00048678509161309.
Biological research in depression has concentrated on 'endogenous' depressions and over the past 30 years has been guided by the amine theory. Neuroendocrine abnormalities in depression have been reported for over 20 years and include changes in the hypothalamic-pituitary-adrenal and thyroid axes, in growth hormone and prolactin secretion. As neurotransmitters regulate neuroendocrine secretion, inter-relationships between neurochemical and neuroendocrine abnormalities may provide a window for understanding the pathophysiology of depression. The availability of these biological markers for depression opens new possibilities for research in psychiatric diagnosis and for management.
抑郁症的生物学研究主要集中在“内源性”抑郁症上，在过去30年里一直受胺理论的指导。抑郁症中的神经内分泌异常已有20多年的报道，包括下丘脑 - 垂体 - 肾上腺轴和甲状腺轴的变化，以及生长激素和催乳素分泌的变化。由于神经递质调节神经内分泌分泌，神经化学和神经内分泌异常之间的相互关系可能为理解抑郁症的病理生理学提供一个窗口。这些抑郁症生物学标志物的可用性为精神科诊断和治疗的研究开辟了新的可能性。
