分层配对研究中两个相关比例差异的齐性检验。

Homogeneity test of difference between two correlated proportions in stratified matched-pair studies.

作者信息

Tang Nian-Sheng, Zhang Bo, Li Hu-Qiong

机构信息

a Department of Statistics , Yunnan University , Kunming , China.

出版信息

J Biopharm Stat. 2013;23(6):1261-80. doi: 10.1080/10543406.2013.834915.

Abstract

Stratified matched-pair studies are often designed for adjusting stratification factors in modern medical researches. This article investigates a homogeneity test of differences between two correlated proportions in stratified matched-pair studies. We propose three test procedures, including an asymptotic test, bootstrap test, and multiple comparison procedures, and determine sample size requirements for such tests in a stratified matched-pair study. Simulation studies are conducted to evaluate the performance of the three test procedures and the accuracy of our derived sample size formulas. Empirical results show that (1) the likelihood ratio statistic is robust, while the score statistic and the modified score statistic are conservative in some cases of our considered settings; (2) the likelihood ratio statistic and the score statistic with the bootstrap method and the MaxT procedure behave satisfactorily in the sense that their type I error rates are close to the pre-given significance level; and (3) the derived sample size formulas are rather accurate. A real example from a clinical laboratory study is used to illustrate the proposed methodologies.

摘要

分层配对研究常用于现代医学研究中对分层因素进行调整。本文研究了分层配对研究中两个相关比例差异的齐性检验。我们提出了三种检验程序,包括渐近检验、自助法检验和多重比较程序,并确定了分层配对研究中此类检验的样本量要求。进行了模拟研究以评估这三种检验程序的性能以及我们推导的样本量公式的准确性。实证结果表明:(1)似然比统计量具有稳健性,而在我们考虑的某些情况下,得分统计量和修正得分统计量较为保守;(2)采用自助法和MaxT程序的似然比统计量和得分统计量表现令人满意,因为它们的I型错误率接近预先给定的显著性水平;(3)推导的样本量公式相当准确。通过一项临床实验室研究的实际例子来说明所提出的方法。

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