抗 tau 抗体：直击目标。
Anti-tau antibodies: hitting the target.
机构信息
Departments of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, College of Medicine University of Florida, Gainesville, FL 32610, USA.
出版信息
Neuron. 2013 Oct 16;80(2):254-6. doi: 10.1016/j.neuron.2013.10.009.
PMID:24139027
Abstract
Immunotherapies targeting tau in mouse models of human tauopathies could have disease-modifying effects. In this issue of Neuron, Yanamandra et al. (2013) use tau antibodies, which effectively block tau seeding in culture, to attenuate tauopathy and improve cognition in mutant tau mouse models.
摘要
针对人类 tau 病模型中 tau 的免疫疗法可能具有疾病修饰作用。在本期《神经元》杂志上，Yanamandra 等人（2013）使用了 tau 抗体，这种抗体可有效阻止 tau 在培养物中的播种，从而减轻 tau 病并改善突变 tau 小鼠模型的认知能力。
Zotero 插件