Department of Neurology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
Department of Neurology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
Gene. 2014 Feb 10;535(2):359-64. doi: 10.1016/j.gene.2013.09.066. Epub 2013 Oct 16.
Associations between 5,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and ischemic stroke have been reported (Ariyaratnam et al., 2007; Banerjee et al., 2007; Casas et al., 2004), but the results of these studies are inconsistent. To investigate the possible associations between the MTHFR gene polymorphism and ischemic stroke, we performed a meta-analysis. Nineteen case-control studies associated with MTHFR gene C667T involving 2223 cases and 2936 controls were included. Heterogeneity among studies was evaluated with I(2) and Egger's test and an inverted funnel plot was used to assess publication bias. Odds ratio (OR) was observed to identify the associations. Statistically significant association with ischemic stroke was identified for allele T polymorphism of MTHFR [fixed-effects OR=1.28, 95% confidence interval (95% CI): 1.17-1.40, P<0.00001] and marginally significant association was detected with genotype CT of MTHFR (fixed-effects OR=1.13, 95% CI: 1.01-127, P=0.04) and genotype TT of MTHFR (fixed-effects OR=1.43, 95% CI: 1.20-1.70, P<0.001). The results suggested that the MTHFR C667T genetic polymorphism was significantly associated with increased risk of ischemic stroke.
5,10-亚甲基四氢叶酸还原酶（MTHFR）基因 C677T 多态性与缺血性卒中之间的关联已有报道（Ariyaratnam 等，2007；Banerjee 等，2007；Casas 等，2004），但这些研究的结果并不一致。为了研究 MTHFR 基因多态性与缺血性卒中之间的可能关联，我们进行了荟萃分析。共纳入 19 项与 MTHFR 基因 C667T 相关的病例对照研究，涉及 2223 例病例和 2936 例对照。采用 I² 和 Egger 检验评估研究间的异质性，并采用倒置漏斗图评估发表偏倚。采用比值比（OR）来确定关联。统计学上发现 MTHFR 等位基因 T 多态性与缺血性卒中显著相关[固定效应 OR=1.28，95%置信区间（95%CI）：1.17-1.40，P<0.00001]，MTHFR 基因型 CT 也存在边缘显著相关[固定效应 OR=1.13，95%CI：1.01-127，P=0.04]，MTHFR 基因型 TT 也存在显著相关[固定效应 OR=1.43，95%CI：1.20-1.70，P<0.001]。结果表明，MTHFR C667T 遗传多态性与缺血性卒中风险增加显著相关。
