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蒙特卡罗法研究适形调强放射治疗中使用非均整滤过强束的可行性和剂量学。

Monte Carlo investigation into feasibility and dosimetry of flat flattening filter free beams.

机构信息

Department of Medical Physics, BC Cancer Agency--Vancouver Island Centre, Vancouver, BC, Canada. Department of Physics and Astronomy, University of Victoria, Victoria, BC, Canada.

出版信息

Phys Med Biol. 2013 Nov 7;58(21):7699-713. doi: 10.1088/0031-9155/58/21/7699. Epub 2013 Oct 18.

Abstract

Flattening filter free (FFF) beams due to their non-uniformity, are sub-optimal for larger field sizes. The purpose of this study was to investigate the incident electron beam distributions that would produce flat FFF (F4) beams without the use of a flattening filter (FF). Monte Carlo (MC) simulations with BEAMnrc and DOSXYZnrc codes have been performed to evaluate feasibility of this approach. The dose distributions in water for open 6 MV beams were simulated using the Varian 21EX linac head model, which will be called the FF model. The FF was then removed from the FF model, and MC simulations were performed using (1) 6 MeV electrons incident on the target and (2) a 6 MeV electron beam with electron angular distributions optimized to provide as flat dose profiles as possible. Configuration (1) represents FFF beam while configuration (2) allowed producing a F4 beam. Optimizations have also been performed to produce flattest profiles for a set of dose rates (DRs) in the range from 1.25 to 2.4 of the DR of FF beam. Profiles and percentage depth doses (PDDs) from 6 MV F4 beams have been calculated and compared to those from the FF beam. Calculated profiles demonstrated improved flatness of the FFF beams. In fact, up to field sizes within the circle of 35 cm diameter the flatness of F4 beam at dmax was better or comparable to that of FF beam. At 20 cm off-axis the dose increased from 52% for FFF to 92% for F4 beam. Also, profiles of F4 beams did not change considerably with depth. PDDs from F4 beams were similar to those of the FFF beam. The DR for the largest modeled (44 cm diameter) F4 beam was higher than the DR from FF beam by a factor of 1.25. It was shown that the DR can be increased while maintaining beam flatness, but at the cost of reduced field size.

摘要

由于不均匀性,无均整过滤器(FFF)射束对于较大的射野尺寸来说并不是最佳选择。本研究的目的是研究产生无均整过滤器(FF)FFF(F4)射束的入射电子束分布。使用 BEAMnrc 和 DOSXYZnrc 代码进行了蒙特卡罗(MC)模拟,以评估这种方法的可行性。使用瓦里安 21EX 直线加速器头模型模拟了水的开 6MV 射束的剂量分布,该模型将称为 FF 模型。然后从 FF 模型中移除 FF,并使用(1)6MeV 电子入射到靶上和(2)优化为提供尽可能平坦剂量分布的电子角分布的 6MeV 电子束进行 MC 模拟。配置(1)代表 FFF 射束,而配置(2)允许产生 F4 射束。还进行了优化,以在 1.25 到 2.4 倍于 FF 射束剂量率(DR)的一组 DR 范围内产生最平坦的轮廓。计算并比较了 6MV F4 射束的轮廓和百分深度剂量(PDD)与 FF 射束的 PDD。计算出的轮廓显示出 FFF 射束的平坦度得到了改善。事实上,在直径为 35cm 的圆内的射野尺寸范围内,dmax 处的 F4 射束的平坦度优于或可与 FF 射束相媲美。在离轴 20cm 处,剂量从 FFF 的 52%增加到 F4 射束的 92%。此外,F4 射束的轮廓随深度变化不大。F4 射束的 PDD 与 FFF 射束相似。最大模拟(直径 44cm)F4 射束的 DR 比 FF 射束高 1.25 倍。结果表明,可以在保持射束平坦度的同时增加 DR,但代价是减小射野尺寸。

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