Uteg K H, Tausendfreund K
Folia Haematol Int Mag Klin Morphol Blutforsch. 1985;112(3):447-55.
For the purpose of establishing a programme of plasmapheresis for manufacturing preparations containing factor VIII, investigations were made to check the expediency of selecting donors. Factor VIII activity (Factor VIII: C) was determined in a total of 165 donors of plasmapheresis. Dependencies of factor-VIII: C on blood group, age and influence of smoking were examined. Depending on the blood group (0 less than A, B, AB) the results found by us showed significant differences in factor-VIII: C. The results are discussed and compared with data in literature. A selection of donors is considered to be reasonable. Increases in gaining factor-VIII are possible by making a pre-selection according to blood groups or better by exact testing respectively.
为了建立用于生产含因子VIII制剂的血浆置换方案，进行了调查以检验选择献血者的适宜性。在总共165名血浆置换献血者中测定了因子VIII活性（因子VIII：C）。研究了因子VIII：C与血型、年龄以及吸烟影响之间的相关性。根据血型（O型少于A型、B型、AB型），我们发现的结果显示因子VIII：C存在显著差异。对结果进行了讨论并与文献数据进行了比较。认为选择献血者是合理的。通过根据血型进行预先筛选，或者更好地通过分别进行精确检测，有可能提高因子VIII的获取量。
