Traczewska M, Chmielewska D, Ochocka M
Folia Haematol Int Mag Klin Morphol Blutforsch. 1985;112(4):525-36.
The in vivo effect of thymus factor X (TFX) on the E-rosetting capacity, the absolute peripheral blood lymphocytes and T-cell number per microliter, the skin test reactivity to recall antigens, and the immunoglobulin production was evaluated in 20 children with acute lymphoblastic leukaemia. The in vitro effect of TFX was also tested. The mean percentage of E-rosettes in these patients increased from 50 to 64%. Although absolute peripheral blood lymphocyte and T-cell number per microliter rose significantly, the mean values did not reach those in healthy children. The tests with recall antigens were positive in 13% of patients prior to immunotherapy and 32% following the therapy. The influence of immunotherapy on infectious episodes and on the stabilisation of remission was also evaluated. TFX in vivo appears to restore immunocompetence, decrease infections, and prolong remissions in children with ALL in remission.
在20例急性淋巴细胞白血病患儿中评估了胸腺因子X（TFX）对E花环形成能力、每微升外周血淋巴细胞绝对值和T细胞数量、对回忆抗原的皮肤试验反应性以及免疫球蛋白产生的体内作用。还测试了TFX的体外作用。这些患者中E花环的平均百分比从50%增加到64%。虽然每微升外周血淋巴细胞绝对值和T细胞数量显著上升，但平均值未达到健康儿童的水平。免疫治疗前13%的患者回忆抗原试验呈阳性，治疗后为32%。还评估了免疫治疗对感染发作和缓解稳定的影响。TFX在体内似乎能恢复免疫能力，减少感染，并延长处于缓解期的急性淋巴细胞白血病患儿的缓解期。
