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点扩散函数和飞行时间重建对 FDG-PET 中淋巴结转移标准化摄取值的影响。

Influences of point-spread function and time-of-flight reconstructions on standardized uptake value of lymph node metastases in FDG-PET.

机构信息

Division of Medical Quantum Science, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Institute of Biomedical Research and Innovation, 2-2, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.

Division of Medical Quantum Science, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

出版信息

Eur J Radiol. 2014 Jan;83(1):226-30. doi: 10.1016/j.ejrad.2013.09.030. Epub 2013 Oct 6.

Abstract

PURPOSE

The purpose of this study was to investigate the effects of point-spread function (PSF) and time-of-flight (TOF) on the standardized uptake value (SUV) of lymph node metastasis in FDG-PET/CT.

MATERIALS AND METHODS

This study evaluated 41 lymph node metastases in 15 patients who had undergone (18)F-FDG PET/CT. The lesion diameters were 2.5 cm or less. The mean short-axis diameter of the lymph nodes was 10.5 ± 3.7 mm (range 4.6-22.8mm). The PET data were reconstructed with baseline OSEM algorithm, with OSEM+PSF, with OSEM+TOF and with OSEM+PSF+TOF. A semi-quantitative analysis was performed using the maximum and mean SUV of lymph node metastases (SUVmax and SUVmean) and mean SUV of normal lung tissue (SUVlung). We also evaluated image quality using the signal-to-noise ratio in the liver (SNRliver).

RESULTS

Both PSF and TOF increased the SUV of lymph node metastases. The combination of PSF and TOF increased the SUVmax by 43.3% and the SUVmean by 31.6% compared with conventional OSEM. By contrast, the SUVlung was not influenced by PSF and TOF. TOF significantly improved the SNRliver.

CONCLUSION

PSF and TOF both increased the SUV of lymph node metastases. Although PSF and TOF are considered to improve small-lesion detectability, it is important to be aware that PSF and TOF influence the accuracy of quantitative measurements.

摘要

目的

本研究旨在探讨点扩散函数(PSF)和飞行时间(TOF)对 FDG-PET/CT 中淋巴结转移标准化摄取值(SUV)的影响。

材料与方法

本研究共纳入 15 例经(18)F-FDG PET/CT 检查的患者,这些患者共存在 41 个直径 2.5cm 及以下的淋巴结转移病灶。淋巴结的平均短轴直径为 10.5±3.7mm(范围 4.6-22.8mm)。使用基线 OSEM 算法、OSEM+PSF、OSEM+TOF 和 OSEM+PSF+TOF 对 PET 数据进行重建。使用淋巴结转移病灶的最大 SUV(SUVmax)和平均 SUV(SUVmean)以及正常肺组织的平均 SUV(SUVlung)对病灶进行半定量分析。同时使用肝脏的信噪比(SNRliver)评估图像质量。

结果

PSF 和 TOF 均能提高淋巴结转移病灶的 SUV 值。与常规 OSEM 相比,PSF 和 TOF 的联合应用使 SUVmax 增加了 43.3%,SUVmean 增加了 31.6%。然而,PSF 和 TOF 对 SUVlung 没有影响。TOF 显著提高了 SNRliver。

结论

PSF 和 TOF 均能提高淋巴结转移病灶的 SUV 值。虽然 PSF 和 TOF 被认为能提高小病灶的检出率,但需要注意的是,PSF 和 TOF 会影响定量测量的准确性。

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