Hotsumi Hirotoshi, Ishii Shirou, Suenaga Hiroki, Sugawara Shigeyasu, Fukushima Kenji, Ito Hiroshi
Department of Radiology, Fukushima Medical University Fukushima, Japan.
Advanced Clinical Research Center, Fukushima Medical University Fukushima, Japan.
Am J Nucl Med Mol Imaging. 2023 Aug 15;13(4):156-163. eCollection 2023.
This study aimed to determine the comparability of tumor-uptake indices of F-FDG in positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) PET/CT and PET/MRI were performed on 55 patients with confirmed primary malignancies. PET/CT preceded PET/MRI in all examinations. Accumulation of F-FDG in lesions and normal organs (brain, liver) was measured. Maximum and peak standardized uptake values (SUVs; SUV and SUV, respectively), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) with margin thresholds of SUV of 50% (MTV; TLG, respectively) were measured as indices for comparison of measurements in tumors. Comparative indices with tumor SUV and liver ratio (TLR), brain ratio (TBR) were calculated. These indices were compared between PET/CT and PET/MRI examinations. The data measured using PET/CT and PET/MRI showed significant correlations for all tumor indices. The correlation was strongest for SUV (r = 0.933), followed by TBR (r = 0.929); and the index ratio of (PET/CT)/(PET/MRI) data was close to 1.0 for TLR (1.00 ± 0.22) and TBR (1.01 ± 0.21), followed by MTV (0.82 ± 0.33) and TLG (1.18 ± 0.45). The values of all indices showed strong correlations between PET/CT and PET/MRI examinations. Among them, TLR, TBR, MTV, and TLG showed a close value and may be useful for comparison of tumor evaluation between two PET systems.
本研究旨在确定正电子发射断层扫描/计算机断层扫描（PET/CT）和正电子发射断层扫描/磁共振成像（PET/MRI）中F-FDG肿瘤摄取指数的可比性。对55例确诊为原发性恶性肿瘤的患者进行了2-[氟-18]-氟-2-脱氧-D-葡萄糖（FDG）PET/CT和PET/MRI检查。在所有检查中，PET/CT先于PET/MRI进行。测量了病变和正常器官（脑、肝）中F-FDG的积聚情况。测量了最大和峰值标准化摄取值（SUVs；分别为SUV和SUV）、代谢肿瘤体积（MTV）以及总病变糖酵解（TLG），以SUV的50%为边缘阈值（分别为MTV；TLG）作为肿瘤测量比较的指标。计算了肿瘤SUV与肝比值（TLR）、脑比值（TBR）的比较指标。对PET/CT和PET/MRI检查的这些指标进行了比较。使用PET/CT和PET/MRI测量的数据显示，所有肿瘤指标均具有显著相关性。SUV的相关性最强（r = 0.933），其次是TBR（r = 0.929）；TLR（1.00±0.22）和TBR（1.01±0.21）的（PET/CT）/（PET/MRI）数据指标比值接近1.0，其次是MTV（0.82±0.33）和TLG（1.18±0.45）。所有指标的值在PET/CT和PET/MRI检查之间均显示出强相关性。其中，TLR、TBR、MTV和TLG显示出接近的值，可能有助于比较两种PET系统之间的肿瘤评估。
