Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, USA.
Vaccine. 2013 Dec 5;31(50):5934-9. doi: 10.1016/j.vaccine.2013.10.044. Epub 2013 Oct 19.
The purpose of this simple study was to characterize a panel of clinical isolates of Mycobacterium tuberculosis obtained from the Western Cape region of South Africa where new clinical vaccine trials are beginning, in the low dose aerosol guinea pig infection model. Most of the strains tested grew well in the lungs and other organs of these animals, and in most cases gave rise to moderate to very severe lung damage. We further observed that the current BCG vaccine was highly protective against two randomly selected strains, giving rise to significantly prolonged survival.
本研究旨在对南非西开普省新临床疫苗试验中获得的一组结核分枝杆菌临床分离株进行鉴定,该地区为低剂量气溶胶豚鼠感染模型。大多数测试的菌株在这些动物的肺部和其他器官中生长良好,并且在大多数情况下导致中度至非常严重的肺部损伤。我们还观察到,目前的卡介苗疫苗对两种随机选择的菌株具有高度保护作用,显著延长了存活时间。