Mejia Edgard M, Nguyen Hieu, Hatch Grant M
Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada; Department of Biochemistry and Medical Genetics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
Chem Phys Lipids. 2014 Apr;179:11-6. doi: 10.1016/j.chemphyslip.2013.10.001. Epub 2013 Oct 19.
Cardiolipin is a major phospholipid in mitochondria and is involved in the generation of cellular energy in the form of ATP. In mammalian and eukaryotic cells it is synthesized via the cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol phosphate pathway. This brief review will describe some of the more recent studies on mammalian cardiolipin biosynthesis and provide an overview of regulation of cardiolipin biosynthesis. In addition, the important role that this key phospholipid plays in disease processes including heart failure, diabetes, thyroid hormone disease and the genetic disease Barth Syndrome will be discussed.
心磷脂是线粒体中的一种主要磷脂，参与以三磷酸腺苷（ATP）形式产生细胞能量的过程。在哺乳动物和真核细胞中，它通过胞苷-5'-二磷酸-1,2-二酰基-sn-甘油磷酸途径合成。这篇简短的综述将描述一些关于哺乳动物心磷脂生物合成的最新研究，并概述心磷脂生物合成的调控。此外，还将讨论这种关键磷脂在包括心力衰竭、糖尿病、甲状腺激素疾病和遗传性疾病巴特综合征在内的疾病过程中所起的重要作用。
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