Sato Y, Watanabe S, Kodama T, Goto M, Shimosato Y
Jpn J Clin Oncol. 1985 Sep;15(3):537-44.
One hundred and one cases of lung cancer were immunohistochemically studied for stainability with Leu-7 (anti-myelin fiber associated glycoprotein) and OKT-9 (anti-transferrin receptor) monoclonal antibodies. All small cell carcinomas and carcinoid tumors were positively stained by Leu-7, and 22 of 41 differentiated adenocarcinomas were also positively stained, especially well-differentiated Clara cell-type adenocarcinoma, (11/14 cases). However, only one of 26 squamous cell carcinomas, one of six large cell carcinomas, one of six adenosquamous carcinomas and none of 16 poorly differentiated adenocarcinomas were stained by Leu-7. On the other hand, all squamous cell carcinomas (26/26 cases), 10 of the 16 poorly differentiated adenocarcinomas, four of the six large cell carcinomas showed positive membranous staining with OKT-9. However, only one of 41 differentiated adenocarcinomas and no small cell carcinomas nor carcinoid tumors were stained by OKT-9. The stainability of lung cancer by these antibodies is discussed.
应用抗髓鞘纤维相关糖蛋白的Leu-7和抗转铁蛋白受体的OKT-9单克隆抗体，对101例肺癌进行免疫组织化学染色研究。所有小细胞癌和类癌均被Leu-7阳性染色，41例分化型腺癌中的22例也呈阳性染色，尤其是高分化的Clara细胞型腺癌（14例中的11例）。然而，26例鳞状细胞癌中只有1例、6例大细胞癌中只有1例、6例腺鳞癌中只有1例被Leu-7染色，16例低分化腺癌均未被Leu-7染色。另一方面，所有鳞状细胞癌（26/26例）、16例低分化腺癌中的10例、6例大细胞癌中的4例呈OKT-9膜阳性染色。然而，41例分化型腺癌中只有1例被OKT-9染色，小细胞癌和类癌均未被OKT-9染色。文中对肺癌与这些抗体的染色性进行了讨论。
