Syngene International Ltd., Biocon Park, Plot Nos. 2 & 3, Bommasandra IV Phase, Jigani Link Road, Bangalore - 560 099, India.
Org Biomol Chem. 2013 Dec 14;11(46):8065-72. doi: 10.1039/c3ob41592a.
An exceptionally stereoselective and general synthesis of (Z)-α-haloacrylates, ready to undergo various synthetic transformations, has been demonstrated from α-haloacetates and aldehydes in a one-pot manner via the titanium-enolate based asymmetric aldol condensation. Besides being an expedient synthetic procedure, the ready availability of diverse α-haloacetates, exceptional stereoselectivity, and high yields make the process a versatile transformation in organic synthesis. The potential of this method in up-scaling operations has been illustrated.
已证明，通过钛烯醇盐基不对称醛醇缩合反应，可从α-卤代乙酸盐和醛一锅法制备（Z）-α-卤代丙烯酸酯（立体选择性极高，适用于各种合成转化）。这种方法不仅是一种简便的合成方法，而且具有多种α-卤代乙酸盐易得、立体选择性高、产率高等优点，使其成为有机合成中一种通用的转化方法。该方法在扩大规模操作中的潜力已得到说明。
