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中东呼吸综合征新型冠状病毒MERS-CoV感染。流行病学及转归最新情况。

Middle East respiratory syndrome novel corona MERS-CoV infection. Epidemiology and outcome update.

作者信息

Al-Tawfiq Jaffar A, Assiri Abdullah, Memish Ziad A

机构信息

Ministry of Health, Al Faisal University, Riyadh, Kingdom of Saudi Arabia.

出版信息

Saudi Med J. 2013 Oct;34(10):991-4.

Abstract

Middle East respiratory syndrome coronavirus MERS-CoV is a newly emerging respiratory virus with a high case fatality rate among identified cases. The virus is thought to cause a severe disease in patients with underlying comorbidities. The identification of asymptomatic patients and mild cases among family and healthcare worker contacts of confirmed cases indicates a wider spectrum of clinical manifestation of the disease. The majority of patients presented with fever 98%, fever with cough 83%, and shortness of breath 72%. Radiographic manifestations range from unilateral infiltrate 43%, to increased bronchovascular markings 17%, and diffuse reticulonodular pattern 4%. Our understanding of the epidemiology and clinical presentation of the disease is increasing overtime. It is still not known what the source of the virus is and what the best treatment modality should be.

摘要

中东呼吸综合征冠状病毒(MERS-CoV)是一种新出现的呼吸道病毒,在已确诊病例中病死率很高。该病毒被认为会在患有基础合并症的患者中引发严重疾病。在确诊病例的家属和医护人员接触者中发现无症状患者和轻症病例,这表明该疾病的临床表现范围更广。大多数患者出现发热(98%)、发热伴咳嗽(83%)和气促(72%)。影像学表现从单侧浸润(43%)到支气管血管纹理增多(17%)以及弥漫性网状结节状阴影(4%)不等。随着时间的推移,我们对该疾病的流行病学和临床表现的了解在不断增加。目前仍不清楚该病毒的来源以及最佳治疗方式应该是什么。

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