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[显微镜下结肠炎——与临床实践相关的新见解]

[Microscopic colitis--new insights relevant to clinical practice].

作者信息

Miehlke S, Aust D, Madisch A

机构信息

Facharztzentrum Eppendorf, Magen-Darm-Zentrum, Hamburg.

Universitätsklinikum, Institut für Pathologie, Dresden.

出版信息

Z Gastroenterol. 2013 Dec;51(12):1389-94. doi: 10.1055/s-0033-1355518. Epub 2013 Oct 21.

Abstract

Microscopic colitis is an increasingly recognised chronic inflammatory bowel disease associated with watery, non-bloody diarrhoea. In addition, many patients suffer from abdominal pain, nocturnal diarrhoea, urgency and incontinence. The two traditional histological subtypes are collagenous colitis and lymphocytic colitis. A novel third subgroup is the so-called incomplete microscopic colitis which is clinically indistinguishable. At present, budesonide is the only evidenced-based effective therapy, however many problems in the long-term treatment strategy are still unsolved. The present paper reviews new developments in microscopic colitis which are relevant for clinical practice.

摘要

显微镜下结肠炎是一种日益被认识到的慢性炎症性肠病,与水样、非血性腹泻相关。此外,许多患者还伴有腹痛、夜间腹泻、便急和大便失禁。两种传统的组织学亚型是胶原性结肠炎和淋巴细胞性结肠炎。一种新的第三亚组是所谓的不完全性显微镜下结肠炎,其在临床上难以区分。目前,布地奈德是唯一有循证依据的有效疗法,然而长期治疗策略中的许多问题仍未解决。本文综述了与临床实践相关的显微镜下结肠炎的新进展。

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