Div. of Gastroenterology and Hepatology, Dept. of Clinical and Experimental Medicine, Faculty of Health Science, Linköping University, Sweden.
J Crohns Colitis. 2012 Oct;6(9):932-45. doi: 10.1016/j.crohns.2012.05.014. Epub 2012 Jun 15.
Microscopic colitis (MC) is an inflammatory bowel disease presenting with chronic, non-bloody watery diarrhoea and few or no endoscopic abnormalities. The histological examination reveals mainly two subtypes of MC, lymphocytic or collagenous colitis. Despite the fact that the incidence in MC has been rising over the last decades, research has been sparse and our knowledge about MC remains limited. Specialists in the field have initiated the European Microscopic Colitis Group (EMCG) with the primary goal to create awareness on MC. The EMCG is furthermore a forum with the intention to promote clinical and basic research. In this article statements and comments are given that all members of the EMCG have considered being of importance for a better understanding of MC. The paper focuses on the newest updates in epidemiology, symptoms and diagnostic criteria, pathophysiology and highlights some unsolved problems. Moreover, a new treatment algorithm is proposed on the basis of new evidence from well-designed, randomized control trials.
显微镜下结肠炎(MC)是一种炎症性肠病,表现为慢性、非血性水样腹泻,内镜下少有或无异常。组织学检查主要显示 MC 的两种亚型,即淋巴细胞性或胶原性结肠炎。尽管过去几十年来 MC 的发病率一直在上升,但研究仍然很少,我们对 MC 的认识仍然有限。该领域的专家发起了欧洲显微镜下结肠炎小组(EMCG),主要目的是提高对 MC 的认识。EMCG 还是一个旨在促进临床和基础研究的论坛。在本文中,给出了所有 EMCG 成员认为对更好地了解 MC 重要的陈述和评论。本文重点介绍了流行病学、症状和诊断标准、病理生理学方面的最新更新,并强调了一些尚未解决的问题。此外,根据精心设计的随机对照试验的新证据,提出了一种新的治疗算法。