Mathers D A
Neurosci Lett. 1985 Sep 30;60(2):121-6. doi: 10.1016/0304-3940(85)90231-9.
The extracellular patch clamp method was used to study the influence of pentobarbital (PB) on membrane channels induced by gamma-aminobutyric acid (GABA) in cultured mouse spinal neurons. PB (200 microM) increased the probability of finding GABA-sensitive channels in the open state; it also increased the average frequency at which GABA-induced single channel currents occur, without decreasing the number of data sweeps which showed no single channel activity. These results indicate that PB potentiates GABA responses by promoting burst-like openings of the GABA-sensitive channel.
采用细胞外膜片钳技术研究戊巴比妥（PB）对培养的小鼠脊髓神经元中γ-氨基丁酸（GABA）诱导的膜通道的影响。PB（200微摩尔）增加了处于开放状态的GABA敏感通道的发现概率；它还增加了GABA诱导的单通道电流出现的平均频率，而没有减少未显示单通道活性的数据扫描次数。这些结果表明，PB通过促进GABA敏感通道的爆发样开放来增强GABA反应。
