Zhai Yuan-Kun, Guo Xin, Pan Ya-Lei, Niu Yin-Bo, Li Chen-Rui, Wu Xiang-Long, Mel Qi-Bing
Key Laboratory for Space Bioscience and Biotechnology, College of Life Science, Northwestern Polytechnical University, Xi'an, China.
Pharmazie. 2013 Sep;68(9):713-22.
The purpose of this systematic review is to assess the efficacy and pharmacological profiles of Herba Epimedii in osteoporosis therapy. Four databases were extensively retrieved that include two Chinese electronic databases (VIP Information and CNKI) and two English electronic databases (CA and MEDLINE). Herba Epimedii has been an important traditional herbal medicine for centuries in China and other Asian countries. Recently, quite a few pharmacological effects of Herba Epimedii, its extracts and active components have been identified that include improving bone health and cardiovascular function, regulating hormone level, modulating immunological function, and inhibiting tumor growth. The anti-osteoporosis activity of Herba Epimedii and its extracts have attracted world-wide attention. The literature search has revealed that a lot of studies have recently been carried out related to the bone-strengthening activity of Herba Epimedii and some of its active compounds, such as total flavonoids and icariin. Pharmacokinetic and toxicity studies have confirmed the efficacy and safety of Herba Epimedii and its most abundant active component icariin, while only a few authors have reviewed the anti-osteoporosis properties of the plants. So we summarize the work of various investigators on the effects of Herba Epimedii, its extracts and active components against osteoporosis. The underlying mechanism of osteoprotective action, derivatives of icariin, animal models and cell lines used in the research were also reviewed in this paper.
本系统评价的目的是评估淫羊藿在骨质疏松症治疗中的疗效和药理特性。广泛检索了四个数据库，包括两个中文电子数据库（维普资讯和中国知网）和两个英文电子数据库（化学文摘和医学期刊数据库）。淫羊藿在中国和其他亚洲国家数百年以来一直是一种重要的传统草药。最近，已确定淫羊藿及其提取物和活性成分具有不少药理作用，包括改善骨骼健康和心血管功能、调节激素水平、调节免疫功能以及抑制肿瘤生长。淫羊藿及其提取物的抗骨质疏松活性已引起全球关注。文献检索表明，最近已开展了许多与淫羊藿及其某些活性化合物（如总黄酮和淫羊藿苷）的强化骨骼活性相关的研究。药代动力学和毒性研究已证实淫羊藿及其含量最丰富的活性成分淫羊藿苷的疗效和安全性，而仅有少数作者对该植物的抗骨质疏松特性进行过综述。因此，我们总结了不同研究者关于淫羊藿及其提取物和活性成分抗骨质疏松作用的研究工作。本文还综述了其骨保护作用的潜在机制、淫羊藿苷的衍生物、研究中使用的动物模型和细胞系。
