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[抑制试验在抗甲状腺药物治疗过程控制中的应用:一种体内核医学程序的复兴?]

[The suppression test in the control of the course of antithyroid drug therapy: renaissance of an in vivo nuclear medicine procedure?].

作者信息

Reiners C, Becker W, Börner W

出版信息

Nuklearmedizin. 1985 Jun;24(3):135-40.

PMID:2414740
Abstract

Measurements of thyroidal suppressibility by thyroid hormones belong to the diagnostic program in nuclear medicine for more than 30 years. Suppression tests are used in follow-up of antithyroidal treatment to predict remission or relapse of hyperthyroidism. Recently, the number of publications dealing with suppression tests has been increasing. Apparently, non-suppressibility of the thyroid after antithyroidal treatment for about 1 year corresponds to a rate of relapse of about 70% whereas in the case of a positive suppression test, the relapse rate amounts to about 20% only. The diagnostic procedures described in the literature are different with respect to radiopharmaceuticals, activity doses, thyroid hormone suppression and, above all, to the time of uptake measurements. After a critical discussion of the literature, a modern diagnostic procedure for the suppression test is proposed using 123I or 99mTc and a computer-assisted gamma camera.

摘要

甲状腺激素对甲状腺抑制性的测量属于核医学诊断程序已有30多年。抑制试验用于抗甲状腺治疗的随访,以预测甲亢的缓解或复发。最近,有关抑制试验的出版物数量一直在增加。显然,抗甲状腺治疗约1年后甲状腺不被抑制对应着约70%的复发率,而在抑制试验阳性的情况下,复发率仅约为20%。文献中描述的诊断程序在放射性药物、活性剂量、甲状腺激素抑制方面,尤其是在摄取测量时间方面存在差异。在对文献进行批判性讨论后,提出了一种使用123I或99mTc以及计算机辅助γ相机的现代抑制试验诊断程序。

相似文献

1
[The suppression test in the control of the course of antithyroid drug therapy: renaissance of an in vivo nuclear medicine procedure?].[抑制试验在抗甲状腺药物治疗过程控制中的应用:一种体内核医学程序的复兴?]
Nuklearmedizin. 1985 Jun;24(3):135-40.
2
PREDICTION OF RELAPSE FROM HYPERTHYROIDISM FOLLOWING ANTITHYROID MEDICATION WITHDRAWAL USING TECHNETIUM THYROID UPTAKE SCANNING.使用锝甲状腺摄取扫描预测抗甲状腺药物停药后甲亢复发。
Endocr Pract. 2017 Apr 2;23(4):466-470. doi: 10.4158/EP161523.OR.
3
[Four-year follow-up of thyrotoxic patients treated with antithyroid drugs bases on thyroid suppressibility-Prognostic value of the 20-min 131-I thyroid uptake (author's transl)].基于甲状腺抑制性用抗甲状腺药物治疗的甲状腺毒症患者的四年随访——20分钟131碘甲状腺摄取的预后价值(作者译)
Ann Endocrinol (Paris). 1980 Mar-Apr;41(2):95-105.
4
[Hyperthyroidism].[甲状腺功能亢进症]
Schweiz Rundsch Med Prax. 1994 Jan 18;83(3):61-4.
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[20 min 99mTc thyroid uptake (author's transl)].[20分钟99m锝甲状腺摄取率(作者译)]
Med Klin. 1975 Jan 24;70(4):154-7.
6
Thyroid suppressibility: follow-up for two years after antithyroid treatment.甲状腺抑制性:抗甲状腺治疗后两年的随访
Br Med J. 1971 Apr 3;2(5752):19-22. doi: 10.1136/bmj.2.5752.19.
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[Clinical significance of determination of early thyroidal 131-I uptake rate--relationship with 24-hour 131-I uptake rate].早期甲状腺 131碘摄取率测定的临床意义——与 24 小时 131 碘摄取率的关系
Horumon To Rinsho. 1972 Feb;20(2):107-14.
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Studies of the thyroid iodide "trap" in man.人体甲状腺碘“捕获”的研究。
Recent Prog Horm Res. 1969;25:423-46. doi: 10.1016/b978-0-12-571125-8.50012-0.
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Thyroidal suppressibility after stopping long-term treatment of thyrotoxicosis with anti-thyroid drugs.停用抗甲状腺药物长期治疗甲状腺毒症后的甲状腺抑制性
Metabolism. 1969 Jan;18(1):58-62. doi: 10.1016/0026-0495(69)90133-4.
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[T-lymphocytes, the TRH-test and the suppression test in thyreostatically treated hyperthyroidism].[甲状腺功能亢进症经抗甲状腺药物治疗后的T淋巴细胞、促甲状腺激素释放激素试验及抑制试验]
Verh Dtsch Ges Inn Med. 1975;81:1555-8.

引用本文的文献

1
Potassium iodide (KI) to block the thyroid from exposure to I-131: current questions and answers to be discussed.用于阻止甲状腺暴露于碘-131的碘化钾(KI):有待讨论的当前问题与解答
Radiat Environ Biophys. 2013 May;52(2):189-93. doi: 10.1007/s00411-013-0462-0. Epub 2013 Mar 9.