通过开环/闭环复分解反应的 (+)-克拉维酮 A 和 (-)-克拉维酮 B 的全合成。

Total synthesis of (+)-clavilactone A and (-)-clavilactone B by ring-opening/ring-closing metathesis.

机构信息

Department of Applied Chemistry, Keio University, Hiyoshi , Kohoku-ku, Yokohama 223-8522, Japan.

出版信息

Org Lett. 2013 Nov 1;15(21):5582-5. doi: 10.1021/ol4027842. Epub 2013 Oct 22.

Abstract

The enantioselective total synthesis of natural enantiomers of clavilactones A and B has been achieved. A key feature of the synthesis is the use of a ring-opening/ring-closing metathesis, which allows the one-pot transformation of a strained cyclobutenecarboxylate into a γ-butenolide.

摘要

已实现天然手性异构体克拉维内酯 A 和 B 的对映选择性全合成。该合成的一个关键特点是使用开环/闭环复分解反应，该反应允许将应变环丁烯羧酸酯一锅转化为γ-丁烯内酯。