Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan, 608-737, Republic of Korea.
Environ Toxicol Pharmacol. 2013 Nov;36(3):1097-108. doi: 10.1016/j.etap.2013.09.014. Epub 2013 Sep 28.
The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis and its mechanistic pathways are critical target for cancer therapy. Recently, marine derived compounds, plays major role in cancer research. Several sponge derived compounds such as alkaloids, terpenes, macrocylic lactone and polyketide are leading drugs in the treatment of different types of diseases including cancer. Those marine sponge compounds inhibit cancer cell proliferation and tumor angiogenesis. Hence, this review sheds light on angiogenic regulators and marine sponge derived antiangiogenic compounds for cancer.
“血管生成开关”一词是指肿瘤进展过程中的一个时间限定事件，在此期间，促血管生成和抗血管生成因子之间的平衡发生变化，导致从休眠的无血管增生向过度生长的血管化肿瘤，最终发展为恶性肿瘤。针对血管生成及其机制途径是癌症治疗的关键靶点。最近，海洋来源的化合物在癌症研究中发挥了重要作用。几种海绵衍生的化合物，如生物碱、萜类、大环内酯和聚酮，是治疗包括癌症在内的不同类型疾病的主要药物。这些海洋海绵化合物抑制癌细胞增殖和肿瘤血管生成。因此，本综述重点介绍了血管生成调节剂和海洋海绵来源的抗血管生成化合物在癌症方面的应用。
