新疆房颤人群中 GGCX 基因多态性与华法林剂量的相关性研究。
Association of GGCX gene polymorphism with warfarin dose in atrial fibrillation population in Xinjiang.
机构信息
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, P,R, China.
出版信息
Lipids Health Dis. 2013 Oct 23;12:149. doi: 10.1186/1476-511X-12-149.
OBJECTIVE
To study the effects of γ-glutamyl carboxylase (GGCX) rs2592551 polymorphism on warfarin dose in atrial fibrillation patients in Xinjiang region.
METHODS
Polymerase chain reaction - restriction fragment length polymorphism and direct sequencing methods were used to detect the rs2592551 genotype in 269 atrial fibrillation patients with warfarin administration. The effects of different genotypes on warfarin dose were statistically analyzed.
RESULTS
The rs2592551 polymorphism detection results were 136 cases of wild-type homozygous CC genotype (50.56%), 115 cases of heterozygous CT genotype (42.75%), 18 cases of homozygous TT genotype (6.69%). The allele frequency C was 71.93%, T was 28.07%. The stable warfarin dose average was 2.86 ± 0.61 mg/d in patients with CC genotype, 3.59 ± 0.93 mg/d in patients with CT genotype and 4.06 ± 0.88 mg/d in patients with TT genotype. The warfarin dose in different genotypes were compared, there was statistically significant difference between CC and TT, CC and CT (P <0. 05), but the TT and CT showed no significant difference (P > 0.05).
CONCLUSION
In atrial fibrillation population in Xinjiang, patients with CT and TT genotypes in GGCX gene rs259251 loci required for significantly higher warfarin dose than those with CC genotype. Therefore, rs2592551 polymorphism may one of the factors affecting the warfarin dose in patients with atrial fibrillation.
目的
研究 γ-谷氨酰羧化酶（GGCX）rs2592551 多态性对新疆地区心房颤动患者华法林剂量的影响。
方法
采用聚合酶链反应-限制性片段长度多态性和直接测序法检测 269 例服用华法林的心房颤动患者 rs2592551 基因型，统计分析不同基因型对华法林剂量的影响。
结果
rs2592551 多态性检测结果为野生型纯合 CC 基因型 136 例（50.56%），杂合型 CT 基因型 115 例（42.75%），纯合型 TT 基因型 18 例（6.69%）。等位基因频率 C 为 71.93%，T 为 28.07%。CC 基因型患者华法林稳定剂量平均为 2.86±0.61mg/d，CT 基因型患者为 3.59±0.93mg/d，TT 基因型患者为 4.06±0.88mg/d。不同基因型的华法林剂量比较，CC 与 TT、CC 与 CT 比较差异有统计学意义（P<0.05），但 TT 与 CT 比较差异无统计学意义（P>0.05）。
结论
在新疆地区心房颤动人群中，GGCX 基因 rs259251 位点 CT 和 TT 基因型患者华法林所需剂量明显高于 CC 基因型患者，因此 rs2592551 多态性可能是影响心房颤动患者华法林剂量的因素之一。
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