增强华法林抗凝活性的新型佐剂。
New adjuvants to enhance anticoagulant activity of warfarin.
机构信息
Department of Chemistry, University of Wisconsin-Eau Claire, Eau Claire, WI 54702, USA.
出版信息
Bioorg Med Chem Lett. 2010 Mar 15;20(6):1928-32. doi: 10.1016/j.bmcl.2010.01.123. Epub 2010 Feb 1.
PMID:20167480
Abstract
New adjuvants of warfarin anticoagulant activity have been developed. These compounds, which are 1,4-methano-1,2,3,4-tetrahydroanthracene-9,10-diol derivatives, act synergistically with warfarin to potentiate its anticoagulant effect. None of the compounds tested is an effective oral anticoagulant in the absence of warfarin.
摘要
新型华法林抗凝活性的佐剂已经被开发出来。这些化合物是 1,4-亚甲基-1,2,3,4-四氢蒽-9,10-二醇衍生物，与华法林协同作用增强其抗凝效果。在没有华法林的情况下，测试的化合物都不是有效的口服抗凝剂。
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