Parmentier J, Shrivastav B, Bennett P B
Undersea Biomed Res. 1985 Sep;12(3):259-68.
The effects of halothane and hydrostatic compression have been studied on the voltage-dependent sodium conductances in the squid giant axon. Compression to 150 atmospheres reduced the time course of both the activation and inactivation phases of the sodium current, reduced the amplitude of the peak inward current, and shifted the sodium reversal potential in a slightly hyperpolarizing direction. Halothane also depressed the sodium current amplitude and shifted the reversal potential but did not alter the membrane kinetics. Subsequent compression to 100 ATA did not restore the inward current flux to its control value, nor reverse the shift in the sodium reversal potential. We conclude that pressure and halothane do not act antagonistically at common sites in this preparation.
研究了氟烷和流体静压对乌贼巨大轴突中电压依赖性钠电导的影响。压缩至150个大气压会缩短钠电流激活和失活阶段的时间进程，降低内向电流峰值的幅度，并使钠反转电位向轻度超极化方向移动。氟烷也会降低钠电流幅度并使反转电位发生移动，但不会改变膜动力学。随后压缩至100ATA并不能使内向电流通量恢复到对照值，也不能逆转钠反转电位的移动。我们得出结论，在该标本中，压力和氟烷并非在共同位点产生拮抗作用。
