Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK.
Bioorg Med Chem. 2013 Dec 1;21(23):7392-7. doi: 10.1016/j.bmc.2013.09.047. Epub 2013 Oct 1.
The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC(50)s versus colon (HT29-AK and leukemia (HL60) cell lines.
本文描述了一系列单螺环和双螺环 1,2,4,5-四氧杂环己烷二聚体的合成。选择的分子进行了体外检测，以确定其抗疟和抗癌的潜力。我们的研究表明，几种分子具有很强的纳摩尔抗疟活性和个位数微摩尔抗增殖活性，对结肠（HT29-AK）和白血病（HL60）细胞系有效。
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