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二氢过氧化物和四氧烷与双（苄基）丙酮衍生物的共轭物的合成及抗疟活性。

Synthesis and antimalarial activity of dihydroperoxides and tetraoxanes conjugated with bis(benzyl)acetone derivatives.

机构信息

Departamento de Química, Universidade Federal de Juiz de Fora, Campus Universitário s/n, Martelos, Juiz de Fora, MG, Brazil.

出版信息

Chem Biol Drug Des. 2012 May;79(5):790-7. doi: 10.1111/j.1747-0285.2012.01345.x. Epub 2012 Mar 16.

DOI:10.1111/j.1747-0285.2012.01345.x
PMID:22284812
Abstract

Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC(50)  ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.

摘要

采用多种方法合成了中等至良好产率的对称取代双（芳基甲基）丙酮衍生的二氢过氧化物和四氧杂环烷。其中三种化合物对人类疟原虫疟原虫的血期表现出重要的体外抗疟活性（1.0 μm≤IC50≤5.0 μm）。

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