Perry D J, Davis R K, Duttenhaver J R, Zajtchuk J T, Hauck K H, Major W B, Baumann J C
Am J Clin Oncol. 1985 Oct;8(5):380-3. doi: 10.1097/00000421-198510000-00008.
Eighteen patients with unresectable Stage III or IV squamous cell carcinoma of the head and neck were treated with induction therapy consisting of sequential methotrexate and 5-fluorouracil. This was followed by full course radiation therapy and radical neck dissection for those with residual neck disease. Those with local control were then treated with vinblastine, bleomycin, and cisplatin (VBP). Although 79% of patients achieved a partial or complete response to chemotherapy, only 50% of patients achieved local control. Marked mucositis limited the dose and schedule of radiation therapy. The methotrexate and 5-fluorouracil combination appears to be too toxic for multimodality therapy of advanced head and neck cancer.
18例无法切除的Ⅲ期或Ⅳ期头颈部鳞状细胞癌患者接受了序贯甲氨蝶呤和5-氟尿嘧啶的诱导治疗。随后对颈部有残留病灶的患者进行全疗程放疗和根治性颈清扫术。对局部控制的患者再用长春碱、博来霉素和顺铂（VBP）进行治疗。尽管79%的患者对化疗有部分或完全反应，但只有50%的患者实现了局部控制。严重的黏膜炎限制了放疗的剂量和疗程。甲氨蝶呤和5-氟尿嘧啶联合方案对晚期头颈部癌的多模式治疗似乎毒性过大。
