Rüegg J C
Basic Res Cardiol. 1985;80 Suppl 2:79-82.
In the myocardium the relationship between intracellular free calcium and contraction is not unique but may vary over a wide range. Modulation of calcium sensitivity of the myofibrils may be studied in chemically skinned fibres which are devoid of the sarcoplasmic reticulum and in which the ionic composition of the interfilament space can be controlled and influenced at will. Here we review conditions and mechanisms which either lower or raise the free calcium ion concentration required for half maximal activation of a functionally isolated contractile mechanism.
在心肌中，细胞内游离钙与收缩之间的关系并非单一，而是可能在很大范围内变化。肌原纤维钙敏感性的调节可在化学去膜纤维中进行研究，这种纤维没有肌浆网，且肌丝间空间的离子组成可以随意控制和影响。在此，我们综述了降低或提高功能分离的收缩机制半最大激活所需游离钙离子浓度的条件和机制。
