曲匹地尔及其他5-三唑并-(1, 5-α)-嘧啶衍生物作为108CC5细胞中的钙通道阻滞剂
Trapidil and other 5-triazolo-(1, 5-alpha)-pyrimidine derivatives as calcium channel blockers in 108CC5 cells.
作者信息
Hering S, Bodewei R, Schubert B, Krause E G, Wollenberger A
出版信息
Biomed Biochim Acta. 1985;44(5):K37-41.
The action of trapidil (RocornalR) and its derivatives AR 12-456 and AR 12-160 on the inward calcium current (ICa) was studied in mouse neuroblastoma x rat glioma hybrid cells of the line 108CC5 under voltage clamp conditions by means of a suction pipette method. A dissociation constant of the calcium channel-trapidil complex of 277 microM was estimated for the initial inhibition of ICa by trapidil. Half maximal block of ICa was produced by 80 +/- 20 microM AR 12-456 and 500 +/- 150 microM AR 12-160.
在电压钳制条件下，采用吸移管法，研究了曲匹地尔（RocornalR）及其衍生物AR 12 - 456和AR 12 - 160对108CC5系小鼠神经母细胞瘤×大鼠胶质瘤杂交细胞内向钙电流（ICa）的作用。曲匹地尔对ICa的初始抑制作用的钙通道 - 曲匹地尔复合物解离常数估计为277微摩尔。80±20微摩尔的AR 12 - 456和500±150微摩尔的AR 12 - 160可产生ICa的半数最大阻断。
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