Boldyrev A A, Prokop'eva V D
Nauchnye Doki Vyss Shkoly Biol Nauki. 1985(9):5-13.
The pattern of dependence of catalytic function for a number of key membrane bound enzymes on the state and properties of their lipid environment is analysed in the review presented. Using hexokinase, cytochrome c-oxidase, transport ATPases and other membrane bound oligomeric systems it has been shown that phospholipid bilayer regulates the interaction of protein components of these ensembles in the bilayer. This feature of membrane structures regulates the substrate accessibility and affinity to the corresponding active centres, the formation and a life-time of the oligomeric associates (that is especially important for membrane channels), their stability and so on. As the microviscosity of membrane bilayer is strongly modified not only in the course of pathologic but also in the process of adaptive alterations as well as depending on the day time, season and as a result of action of biologically active substance on membrane, the regulation of the functional activity of membrane proteins by this factor is an effective mode for metabolic control.
在这篇综述中，分析了许多关键膜结合酶的催化功能对其脂质环境状态和性质的依赖模式。通过己糖激酶、细胞色素c氧化酶、运输ATP酶和其他膜结合寡聚体系统表明，磷脂双层调节这些组合体中蛋白质成分在双层中的相互作用。膜结构的这一特性调节底物对相应活性中心的可及性和亲和力、寡聚体缔合体的形成和寿命（这对膜通道尤为重要）、它们的稳定性等。由于膜双层的微粘度不仅在病理过程中，而且在适应性改变过程中，以及取决于白天时间、季节以及生物活性物质对膜的作用而受到强烈改变，因此该因素对膜蛋白功能活性的调节是代谢控制的有效模式。
