探索 N-炔基化亚磺酰胺的反应性：[2 + 2]环加成反应。

Exploring the reactivity of N-alkynylated sulfoximines: [2 + 2]-cycloadditions.

机构信息

Institute of Organic Chemistry, RWTH Aachen University , Landoltweg 1, D-52074 Aachen, Germany.

出版信息

Org Lett. 2013 Nov 1;15(21):5397-9. doi: 10.1021/ol4026028. Epub 2013 Oct 23.

PMID:24151931

Abstract

To assess the potential of N-alkynylated sulfoximines as new (chiral) reagents for organic synthesis, their reactivity profile in numerous synthetic processes is under investigation. When reacted with ketenes, the alkynylated-sulfoximines undergo a [2 + 2]-cycloaddition process to afford sulfoximine-functionalized cyclobutenones in excellent yields.

摘要

为了评估 N-炔基化亚砜亚胺作为新型（手性）试剂在有机合成中的潜力，正在研究它们在众多合成过程中的反应性。当与烯酮反应时，炔基化亚砜亚胺经历[2 + 2]-环加成过程，以优异的收率得到亚砜亚胺官能化的环丁烯酮。