对映选择性合成环庚[b]吲哚：（S）-SIRT1 抑制剂 IV 的克级合成。
Enantioselective synthesis of cyclohepta[b]indoles: gram-scale synthesis of (S)-SIRT1-inhibitor IV.
机构信息
Institute of Organic Chemistry, Leibniz University Hannover , Schneiderberg 1, 30167 Hannover, Germany.
出版信息
Org Lett. 2013 Nov 1;15(21):5472-5. doi: 10.1021/ol4026217. Epub 2013 Oct 23.
PMID:24152090
Abstract
An enantioselective gram-scale synthesis of one of the most potent SIRT1-inhibitors has been accomplished by an unprecedented domino reaction sequence establishing the cyclohepta[b]indole core. This method was developed for application in natural product synthesis of a variety of indole alkaloids.
摘要
通过前所未有的级联反应序列，完成了对最强的 SIRT1 抑制剂之一的对映选择性克级合成，从而构建了环庚[b]吲哚核心。该方法是为在各种吲哚生物碱的天然产物合成中应用而开发的。
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