School of Chemistry and Chemical Engineering, Henan Normal University , Xinxiang 453007, Henan, China, and School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology , Xinxiang 453003, China.
Org Lett. 2013 Nov 1;15(21):5460-3. doi: 10.1021/ol402596g. Epub 2013 Oct 23.
Unsymmetric acridines are synthesized via a one-pot amination/cyclization/aromatization reaction for the first time. With Pd(OAc)2-X-Phos as the catalyst, a series of unsymmetric acridines are obtained in moderate to excellent yields (up to 99% yield). Meanwhile, the diphenylamine intermediate could be isolated, which is evidence of the domino process.
首次通过一锅氨化/环化/芳构化反应合成了不对称吖啶。以 Pd(OAc)2-X-Phos 为催化剂，以中等至优异的收率（高达 99%的收率）得到一系列不对称吖啶。同时，可以分离出二苯胺中间体，这是多米诺反应的证据。
