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Dopamine inhibition of neurotensin-induced increase in Ca2+ influx into rat pituitary cells.

作者信息

Memo M, Carboni E, Trabucchi M, Carruba M O, Spano P F

出版信息

Brain Res. 1985 Nov 18;347(2):253-7. doi: 10.1016/0006-8993(85)90184-2.

DOI:10.1016/0006-8993(85)90184-2
PMID:2415214
Abstract

In this paper, we report that the intracellular mechanism by which neurotensin stimulates prolactin release involves an increase in Ca2+ uptake by pituitary cells rather than an effect on adenylate cyclase system. In addition, dopamine can prevent neurotensin-induced calcium influx by interacting with dopamine D2-receptors which appear to be completely independent of the adenylate cyclase moiety but are coupled to calcium channels.

摘要

相似文献

1
Dopamine inhibition of neurotensin-induced increase in Ca2+ influx into rat pituitary cells.
Brain Res. 1985 Nov 18;347(2):253-7. doi: 10.1016/0006-8993(85)90184-2.
2
Dopaminergic inhibition of prolactin release and calcium influx induced by neurotensin in anterior pituitary is independent of cyclic AMP system.
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3
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Intraventricular injection of neurotensin reduces dopamine D2 agonist binding in rat forebrain and intermediate lobe of the pituitary gland. Relationship to serum hormone levels and nerve terminal coexistence.脑室内注射神经降压素可降低大鼠前脑和垂体中间叶中多巴胺D2激动剂的结合。与血清激素水平和神经末梢共存的关系。
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Multiple coupling of neurohormone receptors with cyclic AMP and inositol phosphate production in anterior pituitary cells.神经激素受体与垂体前叶细胞中环磷酸腺苷和肌醇磷酸生成的多重偶联。
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10
Pharmacological characterization of the D2 dopamine receptor negatively coupled with adenylate cyclase in rat anterior pituitary.大鼠垂体前叶中与腺苷酸环化酶负偶联的D2多巴胺受体的药理学特性
Mol Pharmacol. 1983 May;23(3):576-84.

引用本文的文献

1
Neurotensin stimulates inositol trisphosphate-mediated calcium mobilization but not protein kinase C activation in HT29 cells. Involvement of a G-protein.神经降压素刺激HT29细胞中肌醇三磷酸介导的钙动员，但不激活蛋白激酶C。G蛋白的参与。
Biochem J. 1989 Dec 15;264(3):871-8. doi: 10.1042/bj2640871.
2
Potassium channels involved in the transduction mechanism of dopamine D2 receptors in rat lactotrophs.参与大鼠催乳素细胞中多巴胺D2受体转导机制的钾通道。
J Physiol. 1989 Mar;410:251-65. doi: 10.1113/jphysiol.1989.sp017531.
3
Dopamine D-2 receptors inhibit D-1 stimulated cyclic AMP accumulation in striatum but not limbic forebrain.
多巴胺D-2受体抑制纹状体中由D-1受体刺激引起的环磷酸腺苷积累，但对边缘前脑无此作用。
Naunyn Schmiedebergs Arch Pharmacol. 1987 May;335(5):508-12. doi: 10.1007/BF00169116.
4
Pharmacological and molecular basis for dopamine D-2 receptor diversity.多巴胺D-2受体多样性的药理学和分子基础。
Mol Neurobiol. 1990 Fall-Winter;4(3-4):181-96. doi: 10.1007/BF02780340.
5
B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity.B-HT 920激活与抑制腺苷酸环化酶活性偶联的多巴胺D2受体。
J Neural Transm Gen Sect. 1992;88(2):95-104. doi: 10.1007/BF01244815.