Buamah P K, Skillen A W, Ward A M
Cancer Chemother Pharmacol. 1986;16(1):75-7. doi: 10.1007/BF00255291.
As chemotherapy with adriamycin is accompanied by toxic side effects, early recognition of ineffective treatment is important. Marker kinetics, apparent half-life (AFL) and doubling time (DT), showed that in five patients with advanced hepatocellular carcinoma, adriamycin was ineffective. Failure of the chemotherapeutic regimen was apparent by the third course of treatment.
由于阿霉素化疗伴有毒副作用，早期识别无效治疗很重要。标志物动力学、表观半衰期（AFL）和倍增时间（DT）显示，在5例晚期肝细胞癌患者中，阿霉素治疗无效。化疗方案在第三个疗程时明显失败。
