Inaba T, Kalow W
Clin Pharmacol Ther. 1975 Nov;18(5 Pt 1):558-62. doi: 10.1002/cpt1975185part1558.
The concentrations of amobarbital in saliva and serum were determined in 5 normal adults following ingestion of 120 mg of sodium amobarbital. There was excellent linear relationship between amobarbital concentrations in saliva and serum (r = 0.993); salivary levels were 36.1% of serum levels. Since the pH of saliva was generally lower than that of blood in man, the degree of ionization of amobarbital in serum and saliva had to be taken into consideration. Estimation of the protein binding of amobarbital in serum from concentrations of amobarbital in saliva and serum was in good agreement with the in vitro data of equilibrium dialysis.
在5名正常成年人摄入120毫克异戊巴比妥钠后，测定了他们唾液和血清中异戊巴比妥的浓度。唾液和血清中异戊巴比妥浓度之间存在极好的线性关系（r = 0.993）；唾液水平为血清水平的36.1%。由于人类唾液的pH值通常低于血液，因此必须考虑异戊巴比妥在血清和唾液中的电离程度。根据唾液和血清中异戊巴比妥的浓度估算血清中异戊巴比妥的蛋白结合情况，与平衡透析的体外数据吻合良好。
