Allonen H, Iisalo E, Kangas L, Lammintausta R, Salonen M
Int J Clin Pharmacol Biopharm. 1978 Sep;16(9):420-3.
The pharmacokinetics of digoxin was studied in 14 healthy volunteers using concentrations measured radioimmunologically in the serum, saliva and urine. The subjects were given 0.75 mg of digoxin intravenously. Serum and saliva were obtained over a 72 hr period and urinary excretion rates over 6 or 7 days. Binding of digoxin to serum proteins was determined by ultracentrifugalization. A linear correlation between the serum and saliva concentrations was found. Salivary levels were equal to the unbound fraction in the serum. The half-lives of distribution did not differ between the serum and saliva. An erroneously short half-life of elimination was found in the serum, but in the saliva and urine it was found to be in the range previously reported. Salivary level measurements may be useful in pharmacokinetic studies and may have important clinical implications.
采用放射免疫法测定血清、唾液和尿液中的浓度，对14名健康志愿者进行了地高辛的药代动力学研究。受试者静脉注射0.75mg地高辛。在72小时内采集血清和唾液样本，并在6或7天内测定尿排泄率。通过超速离心法测定地高辛与血清蛋白的结合情况。发现血清和唾液浓度之间呈线性相关。唾液水平与血清中的未结合部分相等。血清和唾液的分布半衰期没有差异。血清中发现消除半衰期错误地缩短，但在唾液和尿液中发现其处于先前报道的范围内。唾液水平测量在药代动力学研究中可能有用，并且可能具有重要的临床意义。
