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Calcitonin gene-related peptide is a potent inhibitor of substance P degradation.

作者信息

Le Greves P, Nyberg F, Terenius L, Hökfelt T

出版信息

Eur J Pharmacol. 1985 Sep 24;115(2-3):309-11. doi: 10.1016/0014-2999(85)90706-x.

DOI:10.1016/0014-2999(85)90706-x
PMID:2415371
Abstract

Calcitonin gene-related peptide (CGRP) was found to potently inhibit a substance P endopeptidase isolated from human CSF. CGRP potentiated substance P irritant actions; a possible mechanism is interaction for a common metabolic step. Somatostatin is another peptide capable of competing with substance P endopeptidase.

摘要

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