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Analysis of hen egg white lysozyme (HEL)-specific delayed type hypersensitivity hybridomas.

作者信息

Ishii N, Aoki I, Aihara Y, Hikawa N, Takahashi T, Okuda K

出版信息

Hybridoma. 1985 Winter;4(4):311-8. doi: 10.1089/hyb.1985.4.311.

DOI:10.1089/hyb.1985.4.311
PMID:2415445
Abstract

Hen egg white lysozyme (HEL) specific delayed type hypersensitivity hybridomas (TDTH hybridomas) were established by fusing HEL specific C3H/HeN (H-2k haplotype) TDTH with BW5147 thymoma cells. TDTH hybridomas, which had Lyt-1+2- and Thy-1.2 antigens on their surfaces, were injected into mouse footpads with HEL antigens, and foot pad swellings were measured 24 h later. Mice with I-Ak haplotype showed strong responses, and their swellings were reduced by anti-I-Ak specific monoclonal antibodies, which suggests that the activity of the hybridomas is restricted by I-Ak. However, TDTH hybridomas did not modulate HEL specific T-cell proliferation responses.

摘要

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